DNMT3A 抗体 (mAb) 货号：E-39206
DNMT3A antibody (mAb)
背景资料：DNMT3A – DNA methyltransferase proteins such as DNMT3A (or DNMT 3A) are involved in DNA methylation, in which a methyl group is added to a cytosine residue on DNA, commonly at the C5 position of a CpG dinucleotide. DNMT3A has been shown to be important in the regulation of specific patterns of DNA methylation. Methylation of mammalian DNA has long been recognized to play a major role in a number of cellular functions such as embryonic development, genetic imprinting, X chromosome inactivation and control of gene expression. DNA methylation is generally associated with transcriptional repression.
Three families of DNMTs have been identified: DNMT1, DNMT2 and DNMT3. TheDNMT3 family, containing two active methyltransferases, DNMT3A & DNMT3B, and one DNMT3-Like protein (DNMT3L), establishes the initial CpG methylation pattern de novo and shows the same propensity for methylating unmethylated duplex DNA as for hemi-methylated DNA. DNMT3A and DNMT3B are encoded by two distinct genes and are strongly expressed in embryonic stem cells. DNMT3A is ubiquitous in mammalian cells.
免疫原：This DNMT3A antibody was raised against a full-length protein corresponding to mouse DNMT3A.
来源宿主：Mouse
反应性：Human, Mouse
应用类型：Validated Applications:
WB: 2 - 4 µg/ml dilution
Published Applications:
ChIP
See reference for experimental details. Individual optimization may be required.
For optimal results, primary antibody incubations should be performed at room temperature. The addition of 0.1% Tween 20 to all Blotto solutions may also reduce background. Individual optimization may be required.
保存建议：Antibodies in solution can be stored at -80°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
定购信息：
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询价 |
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