组蛋白 H3S28ph 抗体 (mAb) 货号：E-39098
Histone H3S28ph antibody (mAb)
背景资料：Histone H3 is one of the core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins and the methylation of cytosine residues in the DNA. Reported histone modifications include acetylation, methylation, phosphorylation, ubiquitylation, glycosylation, ADP-ribosylation, carbonylation and SUMOylation; these modifications play a major role in regulating gene expression.
Ser10 phosphorylation and Ser28 phosphorylation in the tail of H3 have very similar kinetics. Both phosphorylations occur early in mitosis when chromosomes begin to condense and during premature chromosome condensation induced in S-phase cells. These phosphorylated serines are excellent mitotic markers. In contrast to Ser10 phosphorylation, Ser28 phosphorylation has never been observed in interphase.
产品描述：Validated Applications:
ICC/IF: 1:1,000 - 1:5,000 dilution
| Antibody Type: |
Monoclonal |
| Isotype: |
IgG2a |
| Purification: |
Affinity Purified |
|
| Host: |
Rat |
| Molecular Weight: |
17 kDa |
| Reactivity: |
Human, Mouse, Rat |
|
产品应用：
This Histone H3 phospho Ser28 antibody was raised in rat against a peptide corresponding to amino acid residues 23-35 (phospho Ser 28) of human Histone H3.
产品使用：
Purified IgG in 0.1 M Tris-glycine (pH 7.4), 150 mM NaCl and 0.05% sodium azide. Sodium azide is highly toxic. For your convenience, an ascites version (Catalog No. 61325) of this antibody is also available.
温度保存：
Antibodies in solution can be stored at -80°C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
定购信息：
表观遗传学产品全面解决方案列下：
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