重组 PRMT2 蛋白 货号：E-31392
Recombinant PRMT2 protein
背景资料：PRMT2 (Protein Arginine Methyltransferase 2) is a member of the protein arginine N-methyltransferase (PRMT) family that is capable of monomethylating and asymmetrically dimethylating arginine residues. PRMT2 methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, and histone H4. PRMT2, along with NCOA2, acts as a coactivator of androgen receptor (AR)-mediated transactivation. PRMT2 also acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. PRMT2 enhances PGR, PPARϒ, RARA-mediated transactivation and may inhibit NFκB transcription and promote apoptosis. PRMT2 is known to repress E2F1 transcriptional activity in an Rb-dependent manner and may be involved in growth regulation.
产品描述：
Recombinant PRMT2 (accession number NP_996845.1) was expressed in Sf9 cells and contains an N-terminal FLAG tag with an observed molecular weight of 47.6 kDa. The recombinant protein is >80% pure by SDS-PAGE.
产品应用：
Recombinant PRMT2 is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.
Specific Activity: PRMT2 methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, and histone H4.May methylate H3R8 and H4.
产品使用：
Full length recombinant PRMT2 protein expressed in Sf9 cells at a concentration of 0.3 mg/ml in 25 mM HEPES, pH 7.5, 120 mM NaCl, 0.2 mg/ml 3X FLAG peptide and 5% glycerol.
温度保存：
Lyophilized proteins can be stored at -20°C or -80°C, preferably desiccated. Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
定购信息：
表观遗传学产品全面解决方案列下：
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