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Alpha 2 Macroglobulin, Human Plasma |
| 中文名称 |
【A 2 Macroglobulin】天然人血浆α 2 Macroglobulin（1 mg） |
| 供应商 |
BioVision |
产品货号 |
7296-1000 |
| 产品报价 |
客服1： 客服2： |
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购买方式
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银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系010-52406250. |
| 产品新闻 |
| 微信号：AD-Bio |
订阅号： Bio-888 |
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| 背景资料 |
Alpha 2 macroglobulin (A2M) is a major serum protein found at concentrations of 240 mg per 100 ml in men and 290 mg per 100 ml in women. It functions as a broad-spectrum protease-binding protein. It is produced by the liver, and is a major component of the alpha-2 band in protein electrophoresis. It is a large plasma glycoprotein that has long been known as an irreversible inhibitor of a variety of proteinases. More recently, it has been reported that numerous growth factors, cytokines and hormones bind to alpha 2M through diverse mechanisms. A2M is also produced in the brain where it binds multiple extracellular ligands and is internalized by neurons and astrocytes. In the brain of Alzheimer's disease (AD) patients, A2M has been localized to diffuse amyloid plaques. A2M also binds soluble beta-amyloid, of which it mediates degradation. Protease-conjugated alpha2-macroglobulin is selectively bound by cells contacting the body fluids and alpha2-macroglobulin and its protease cargo are then internalized and degraded in secondary lysosomes of those cells. In addition to this function as an agent for protease clearance, Alpha2-macroglobulin binds a variety of other ligands, including several peptide growth factors and modulates the activity of a lectin-dependent cytolytic pathway in arthropods. Multifunctional, it promotes growth of mammalian cells in culture, stimulates the regeneration of lymphocytes in irradiated mice, possesses a transport function for zinc and is a proteinase inhibitor that controls the clotting and fibrinolytic system. Clinically levels are increased in liver cirrhosis, nephrotic syndrome, diabetes, and severe burn cases. |
| 产品描述 |
该天然人血浆α 2 Macroglobulin产品为冻干形式.具体样式见英文说明：Lyophilized from 30 mM Na Phosphate, pH 7.0, with glycine as a stabilizer. |
| 来源宿主 |
提供的【A 2 Macroglobulin】天然人血浆α 2 Macroglobulin产品的来源为人血浆中分离. |
| 序列 |
天然人血浆α 2 Macroglobulin蛋白产品，又称C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, A2M, CPAMD5, FWP007.其对应NCBI基因号为2，对应Accession号为P01023.
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| 溶解建议 |
天然人血浆α 2 Macroglobulin产品请按照说明书建议进行溶解操作：In water or aqueous buffer. |
| 保存建议 |
在您收到艾美捷发出的【A 2 Macroglobulin】天然人血浆α 2 Macroglobulin产品后，建议将其置于-20°C保存. |
| 产品说明书 |
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