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Human CellExp HGFR/c-MET, human recombinant |
| 中文名称 |
【HGFR】人源细胞表达的重组人肝细胞生长因子R/c-MET（20ug） |
| 供应商 |
BioVision |
产品货号 |
7393-20 |
| 产品报价 |
客服1： 客服2： |
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购买方式
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银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系010-52406250. |
| 产品新闻 |
| 微信号：AD-Bio |
订阅号： Bio-888 |
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| 背景资料 |
Hepatocyte growth factor receptor (HGFR), also known as mesenchymal-epithelial transition factor (MET), c-Met, and is a glycosylated receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGFR protein possesses tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. HGFR is normally expressed by cells of epithelial origin, while expression of HGF is restricted to cells of mesenchymal origin. Upon HGF stimulation, HGFR induces several biological responses that collectively give rise to a program known as invasive growth. Abnormal HGFR activation in cancer correlates with poor prognosis, where aberrantly active HGFR triggers tumor growth, formation of new blood vessels (angiogenesis) that supply the tumor with nutrients, and cancer spread to other organs (metastasis). HGFR is deregulated in many types of human malignancies, including cancers of kidney, liver, stomach, breast, and brain. Normally, only stem cells and progenitor cells express HGFR, However, cancer stem cells are thought to hijack the ability of normal stem cells to express HGFR, and thus become the cause of cancer persistence and spread to other sites in the body. Various mutations in the HGFR gene are associated with papillary renal carcinoma. HGFR mediates a complex program known as invasive growth. Activation of HGFR triggers mitogenesis, and morphogenesis. |
| 产品描述 |
该人源细胞表达的重组人肝细胞生长因子R/c-MET产品为冻干形式.具体样式见英文说明：Lyophilized from 0.22 um filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization. |
| 来源宿主 |
提供的【HGFR】人源细胞表达的重组人肝细胞生长因子R/c-MET产品的来源为人胚肾HEK293细胞重组表达重组表达. |
| 序列 |
人源细胞表达的重组人肝细胞生长因子R/c-MET蛋白产品，又称MET, AUTS9, HGFR, RCCP2, c-Met.其对应NCBI基
因号为4233，对应Accession号为P08581.
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| 溶解建议 |
人源细胞表达的重组人肝细胞生长因子R/c-MET产品请按照说明书建议进行溶解操作：Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 ug/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C. |
| 保存建议 |
在您收到发出的【HGFR】人源细胞表达的重组人肝细胞生长因子R/c-MET产品后，建议将其置于-20°C保存. |
| 产品说明书 |
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