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Human CellExp MMP-9, human recombinant |
| 中文名称 |
【MMP 9】人源细胞表达的重组人基质金属蛋白酶9（50 ug） |
| 供应商 |
BioVision |
产品货号 |
7246-50 |
| 产品报价 |
客服1： 客服2： |
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购买方式
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银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系010-52406250. |
| 产品新闻 |
| 微信号：AD-Bio |
订阅号： Bio-888 |
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| 背景资料 |
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive pro-proteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. Thrombospondins, intervertebral disc proteins, regulate the effective levels of matrix metalloproteinases (MMPs) 2 and 9, which are key effectors of ECM remodeling. Matrix metallopeptidase 9 (MMP-9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), CLG4B, is secreted from neutrophils, macrophages, and a number of transformed cells, and is the most complex family member in terms of domain structure and regulation of its activity. Structurally, MMP9 maybe be divided into five distinct domains: a pro-domain which is cleaved upon activation, a gelatin binding domain consisting of three contiguous fibronectin type II units, a catalytic domain containing the zinc binding site, a proline rich linker region, and a carboxyl terminal hemopexin like domain. This enzyme degrades various substrates including gelatin, collagen types IV and V, and elastin. MMP9 is involved in a variety of autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis, and be regarded as a potential therapeutic target. |
| 产品描述 |
该人源细胞表达的重组人基质金属蛋白酶9产品为冻干形式.具体样式见英文说明：Lyophilized from 0.22 um filtered solution in PBS, pH 7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization. |
| 来源宿主 |
提供的【MMP 9】人源细胞表达的重组人基质金属蛋白酶9产品的来源为人胚胎肾HEK293细胞重组表达重组表达. |
| 序列 |
人源细胞表达的重组人基质金属蛋白酶9蛋白产品，又称MMP9, CLG4B, GELB, MANDP2, MMP-9, Matrix Meta
lloproteinase-9.其对应NCBI基因号为4318，对应Accession号为P14780.
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| 溶解建议 |
人源细胞表达的重组人基质金属蛋白酶9产品请按照说明书建议进行溶解操作：Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 ug/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C. |
| 保存建议 |
在您收到发出的【MMP 9】人源细胞表达的重组人基质金属蛋白酶9产品后，建议将其置于-20°C保存. |
| 产品说明书 |
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