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RIPK2, Active |
中文名称 |
【RIPK2】RIPK2蛋白,有活性的(5 ug) |
供应商 |
BioVision |
产品货号 |
7747-5 |
产品报价 |
客服1: 客服2: |
购买方式
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银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系010-52406250. |
产品新闻 |
微信号:AD-Bio |
订阅号: Bio-888 |
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背景资料 |
RIPK2 (RIP2; RICK) is a death domain-containing protein kinase. Inohara identified cDNAs encoding a predicted 540-amino acid protein RICK, which contains an N-terminal serine/threonine kinase catalytic domain and a C-terminal caspase activation and recruitment domain. Inohara also demonstrated that RICK is a novel kinase that may regulate apoptosis induced by the FAS receptor pathway (1). McCarthy found that overexpression of RIP2 signaled both cell death and NF-kappa-B activation (2). Thome reported that RICK specifically interacted with the CARD of ICE/caspase-1, and this interaction correlated with the processing of pro-caspase-1 and the formation of the active caspase-1 p20 (3). Chin generated Ripk2-deficient mice and concluded that RIPK2 is implicated in the innate response to pathogens by NOD and TLR-induced cell signaling and mediates cytokine-induced Ifng production in Th1 and NK cells (4). Also Kobayashi demonstrated that RIPK2 is required for signaling through both TLR and NOD protein family members in the innate immune system as well as for appropriate TCR signaling in the adaptive immune response (5). |
产品描述 |
该RIPK2蛋白,有活性的产品为液体形式.具体样式见英文说明:Recombinant proteins in storage buffer (50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol). |
来源宿主 |
提供的【RIPK2】RIPK2蛋白,有活性的产品的来源为Sf9昆虫细胞-杆状病毒中重组表达. |
序列 |
RIPK2蛋白,有活性的蛋白产品,又称RIPK, receptor-interacting serine-threonine kinase
2, CARD-containing interleukin-1 beta-converting enzyme-associated kin
ase, Short name=CARD-containing IL-1 beta ICE-kinase, RIP-like-interac
ting CLARP kinase, Receptor-interacting protein 2, Tyrosine-protein ki
nase RIPK2 .其对应NCBI基因号为23683,NCBI基因别称为PRKD3源,对应Accession号为NM_005813.该蛋
白产品又称ripk 2, RIPK-2, Active RIPK2, RIPK2, RIPK, human RIPK2, active ki
nase, active kinases, recombinant RIPK2, recombinant RIPK, kinase acti
vity assay, protein kinase等.
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溶解建议 |
提供的RIPK2蛋白,有活性的 产品为液态形式溶解于储存液(50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% 甘油)中. |
保存建议 |
在您收到发出的【RIPK2】RIPK2蛋白,有活性的产品后,建议将其置于-80°C保存. |
产品说明书 |
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