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Epigenetics |
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【Antithrombin III】天然人血浆Anti凝血酶 III（7298-100） |
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Antithrombin III, Human Plasma |
| 中文名称 |
【Antithrombin III】天然人血浆Anti凝血酶 III（100 ug） |
| 供应商 |
BioVision |
产品货号 |
7298-100 |
| 产品报价 |
客服1： 客服2： |
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购买方式
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银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系010-52406250. |
| 产品新闻 |
| 微信号：AD-Bio |
订阅号： Bio-888 |
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| 背景资料 |
SerpinC1, also known as antithrombin III (AT III), is a member of the serpin superfamily of serine protease inhibitors, and has been found to be a marker for disseminated intravascular coagulation (DIC) and to be of prognostic significance in septic patients. SerpinC1 synthesized in the liver is the principal plasma serpin of blood coagulation proteases and inhibits thrombin and other factors such as Xa by the formation of covalently linked complexes. Thus it is one of the most important coagulation inhibitors and the fundamental enzyme for the therapeutical action of heparin. In common with SerpinA5 and D1, the inhibitory activity of SerpinC1 undergoes a dramatic increase in the presence of heparin and other glycosaminoglycans. ATIII mediates the promotion of prostaglandin release, an inhibitor of leucocyte activation and downregulator of many proinflammatory cytokines. Antithrombin III exerts anti-inflammatory properties in addition to its anti-coagulative mechanisms. In animal models of sepsis, ATIII affected cytokine plasma concentrations with a decrease of pro-inflammatory cytokines. The deficiency or functional abnormality of ATIII may result in an increased risk of thromboembolic disease, such as deep vein thrombosis and pulmonary embolism. In addition, it has been reported that SerpinC1 can alter or influence inflammatory processes via inhibition of NF-κB activation or actin polymerization. Antithrombin III is found in normal serum at 15 mg per 100 ml. Found at higher levels in plasma than in serum because of complexing with thrombin during coagulation. Clinically, reduced levels are indicative of hypercoagulability. |
| 产品描述 |
该天然人血浆Anti凝血酶 III产品为冻干形式.具体样式见英文说明：Lyophilized from 50 mM Tris-HCl, pH 8.0, with 150 mM NaCl. |
| 来源宿主 |
提供的【Antithrombin III】天然人血浆Anti凝血酶 III产品的来源为人血浆中分离. |
| 序列 |
天然人血浆Anti凝血酶 III蛋白产品，又称SERPINC1.其对应NCBI基因号为462，对应Accession号为P01008.
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| 溶解建议 |
天然人血浆Anti凝血酶 III产品请按照说明书建议进行溶解操作：In water or aqueous buffer. |
| 保存建议 |
在您收到发出的【Antithrombin III】天然人血浆Anti凝血酶 III产品后，建议将其置于-20°C保存. |
| 产品说明书 |
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