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CAMK1b, Active |
| 中文名称 |
【CAMK1b】CAMK1b蛋白,有活性的（5 ug） |
| 供应商 |
BioVision |
产品货号 |
7729-5 |
| 产品报价 |
客服1： 客服2： |
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购买方式
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银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系010-52406250. |
| 产品新闻 |
| 微信号：AD-Bio |
订阅号： Bio-888 |
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| 背景资料 |
Many of the effects of calcium are mediated via its interaction with calmodulin and the subsequent activation of Ca(2+)/calmodulin-dependent (CaM) kinases. CaM kinases are involved in a wide variety of cellular processes including muscle contraction, neurotransmitter release, cell cycle control, and transcriptional regulation. While CaMKII has been implicated in learning and memory, the biological role of the other multifunctional CaM kinases, CaMKI and CaMKIV, is largely unknown. CaMKIβ, or pregnancy upregulated non-ubiquitously expressed CaM kinase (PNCK), is a 38-kDa serine/threonine kinase whose catalytic domain shares 45-70% identity with members of the CaM kinase family. The gene for CaMKIβ localizes to mouse chromosome X. CaMKIβ is upregulated during intermediate and late stages of murine fetal development with highest levels of expression in developing brain, bone, and gut. CaMKIβ is also expressed in a tissue-specific manner in adult mice with highest levels of expression detected in brain, uterus, ovary, and testis. Interestingly, CaMKIβ expression in these tissues is restricted to particular compartments and appears to be further restricted to subsets of cells within those compartments. The chromosomal localization of CaMKIβ, along with its tissue-specific and restricted pattern of spatial expression during development, suggests that CaMKIβ may be involved in a variety of developmental processes including development of the central nervous system (1). Also CaMKIβ2, an isoform of mCaMKIβ, was mainly identified in the nervous system, including brain, spinal cord, trigeminal ganglion, and retina. Within the CNS, the expression of CaMKIβ2 is detected in the mantle zone, but not in the ventricular zone, suggesting its possible involvement in the differentiation of neurons (2). |
| 产品描述 |
该CAMK1b蛋白,有活性的产品为液体形式.具体样式见英文说明：Recombinant protein in storage buffer (50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol). |
| 来源宿主 |
提供的【CAMK1b】CAMK1b蛋白,有活性的产品的来源为Sf9昆虫细胞-杆状病毒中重组表达. |
| 序列 |
CAMK1b蛋白,有活性的蛋白产品，又称CAMK1b, Calcium/calmodulin-dependent protein kinas
e type I beta chain.其对应NCBI基因号为5568，NCBI基因别称为PKA源，对应Accession号为NM_0027
32.该蛋白产品又称camk 1b, camk-1b, Active CAMK1b, CAMK1b, CAMK, CAMK1, human
CAMK1, active kinase, active kinases, recombinant CAMK1, recombinant C
AMK, kinase activity assay, protein kinase等.
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| 溶解建议 |
提供的CAMK1b蛋白,有活性的 产品为液态形式溶解于储存液(50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% 甘油)中. |
| 保存建议 |
在您收到发出的【CAMK1b】CAMK1b蛋白,有活性的产品后，建议将其置于-80°C保存. |
| 产品说明书 |
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