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FGR, Active |
中文名称 |
【FGR】FGR蛋白,有活性的(5 ug) |
供应商 |
BioVision |
产品货号 |
7724-5 |
产品报价 |
客服1: 客服2: |
购买方式
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银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系010-52406250. |
产品新闻 |
微信号:AD-Bio |
订阅号: Bio-888 |
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背景资料 |
Fgr is a protooncogene that is a unique member of the tyrosine kinase gene family. It is localized to the distal portion of the short arm of human chromosome 1 at p36.1-36.2 by in situ hybridization (1). Certain lymphomas (but not sarcomas or carcinomas) express fgr-related messenger RNA. This transcript is detected in Burkitt’s lymphoma cell lines naturally infected with Epstein-Barr virus (EBV), but not in EBV-negative Burkitt’s lymphoma cells (2). Normal umbilical cord or peripheral blood lymphocyte lines established in vitro by EBV infection also contain detectable c-fgr mRNA. Moreover, a 50-fold increase of the steady-state c-fgr mRNA concentration is observed when uninfected Burkitt’s lymphoma cell lines are deliberately infected with EBV demonstrating the induction of a proto-oncogene in response to infection by a DNA tumour virus. Fgr expression is limited to normal peripheral blood granulocytes, monocytes, and alveolar macrophages, all of which contain 50 to 100 copies of c-fgr mRNA per cell (3). The c-fgr RNA molecules in these cells consisted of partially spliced transcripts containing intron 7 and completely spliced molecules capable of encoding the predicted p55 c-fgr protein. The level of fgr transcripts begin to increase 2 to 4 h after TPA addition, peak at 8 h, and subsequently declined suggesting transient transcriptional activation of fgr during TPA-induced differentiation. Cycloheximide also causes accumulation of c-fgr transcripts in U937 cells. Thus, c-fgr gene is expressed in a tissue- and development-specific fashion and constitutive expression of c-fgr in U937 cells is regulated by a labile transcriptional repressor. |
产品描述 |
该FGR蛋白,有活性的产品为液体形式.具体样式见英文说明:Recombinant protein in storage buffer (50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol). |
来源宿主 |
提供的【FGR】FGR蛋白,有活性的产品的来源为Sf9昆虫细胞-杆状病毒中重组表达. |
序列 |
FGR蛋白,有活性的蛋白产品,又称FGR, Gardner-Rasheed feline sarcoma viral (v-fgr) onc
ogene homolog, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene h
omolog, Proto-oncogene c-Fgr, p55-Fgr, p58-Fgr, p58c-Fgr.其对应NCBI基因号为64
0,NCBI基因别称为BLK源,对应Accession号为P51451.该蛋白产品又称Active FGR, FGR, human FGR,
active kinase, active kinases, recombinant FGR, recombinant FGR, kina
se activity assay, protein kinase等.
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溶解建议 |
提供的FGR蛋白,有活性的 产品为液态形式溶解于储存液(50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% 甘油)中. |
保存建议 |
在您收到发出的【FGR】FGR蛋白,有活性的产品后,建议将其置于-80°C保存. |
产品说明书 |
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