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Epigenetics |
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Epigenetics>【BioVision】 |
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【SHH】重组人Sonic Hedgehog (4010-100) |
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Sonic Hedgehog (SHH), human recombinant |
中文名称 |
【SHH】重组人Sonic Hedgehog (SHH)(100ug) |
供应商 |
BioVision |
产品货号 |
4010-100 |
产品报价 |
客服1: 客服2: |
购买方式
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银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系010-52406250. |
产品新闻 |
微信号:AD-Bio |
订阅号: Bio-888 |
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背景资料 |
Recombinant Human Sonic Hedgehog (SHH) is a highly conserved protein that plays an important role in embryonic development. It is expressed in neural tissue, the gut, and areas of limb development and promotes differentiation and growth in a tissue-specific manner. SHH is synthesized as a 45-kDa precursor protein, which is then cleaved to generate the active 19-kDa N-terminus. SHH interacts with the Patched and Smoothened transmembrane receptors, leading to the activation of GLI family transcription factors. Disruption of any part of this pathway during embryogenesis is associated with birth defects ranging from mild to severe. In adults, abnormal activation of the SHH pathway has been implicated in several forms of cancer. Three mammalian hedgehog genes (sonic, desert, Indian) share about 60% homology. The Cys at position 25 has been substituted with Ile. Human SHH is a non-glycosylated polypeptide consisting of 175 amino acids with a molecular weight of 19,697 Da. |
产品描述 |
该重组人Sonic Hedgehog (SHH)产品为冻干形式.具体样式见英文说明:Lyophilized from a 10 mM sodium phosphate buffer, pH 7.5. |
来源宿主 |
提供的【SHH】重组人Sonic Hedgehog (SHH)产品的来源为大肠杆菌重组表达. |
序列 |
重组人Sonic Hedgehog (SHH)蛋白产品,又称SHH; HHG1; HLP3; HPE3; SMMCI, Sonic hedg
ehog.其对应NCBI基因号为6469,对应Accession号为Q15465.
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溶解建议 |
重组人Sonic Hedgehog (SHH)产品请按照说明书建议进行溶解操作:When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile H |
保存建议 |
在您收到发出的【SHH】重组人Sonic Hedgehog (SHH)产品后,建议将其置于-20°C保存. |
产品说明书 |
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