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MDC, human recombinant |
中文名称 |
【MDC】重组人巨噬细胞来源的趋化因子巨噬细胞来源的趋化因子MDC/CCL22(100 ug) |
供应商 |
BioVision |
产品货号 |
4617-100 |
产品报价 |
客服1: 客服2: |
购买方式
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银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系010-52406250. |
产品新闻 |
微信号:AD-Bio |
订阅号: Bio-888 |
技术微信:hugasis |
销售微:ex-2008 |
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背景资料 |
MDC (CCL22) is a small cytokine that belongs to the CC chemokine family. CCL22 is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. MDC shows chemotactic activity for natural killer cells, chronically activated T lymphocytes, monocytes and dendritic cells. On the other hand, MDC shows a mild activity for primary activated T lymphocytes and has no chemo attractant activity for neutrophils, eosinophils and resting T lymphocytes. MDC may also have a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. MDC interacts with cell surface chemokine receptors CCR4. CCL22 is vastly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. CCL22 is also found in the lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression of CCL22 can be seen in the lung and the spleen and very weak expression in the small intestine. In the lymph node CCL22 is expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+). Furthermore, CCL22 is expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis. In addition, MDC has a role in hindering progression of lung cancer. Moreover, significantly higher CCL22 expression is linked to gastric cancer. |
产品描述 |
该重组人巨噬细胞来源的趋化因子巨噬细胞来源的趋化因子MDC/CCL22产品为冻干形式.具体样式见英文说明:CCL22 filtered (0.4um) and lyophilized from a concentrated solution containing 20mM phosphate buffer & 500mM NaCl pH-7.4. |
来源宿主 |
提供的【MDC】重组人巨噬细胞来源的趋化因子巨噬细胞来源的趋化因子MDC/CCL22产品的来源为大肠杆菌重组表达. |
序列 |
重组人巨噬细胞来源的趋化因子巨噬细胞来源的趋化因子MDC/CCL22蛋白产品,又称C-C motif chemokine 22, Small
-inducible cytokine A22, Macrophage-derived chemokine, MDC (1-69), Sti
mulated T-cell chemotactic protein 1, CC chemokine STCP-1, CCL22, MDC,
SCYA22, ABCD-1, DC/B-CK, MGC34554, A-152E5.1.其对应NCBI基因号为6367,对应Access
ion号为O00626.
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溶解建议 |
重组人巨噬细胞来源的趋化因子巨噬细胞来源的趋化因子MDC/CCL22产品请按照说明书建议进行溶解操作:It is recommended to reconstitute the lyophilized CCL22 in sterile 18MΩ-cm H2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
保存建议 |
在您收到发出的【MDC】重组人巨噬细胞来源的趋化因子巨噬细胞来源的趋化因子MDC/CCL22产品后,建议将其置于-20°C保存. |
产品说明书 |
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