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Epigenetics |
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| Epigenetics>【AMQUAR】 |
062.【表观遗传-RNA甲基化】萌货！奔跑吧！！RNA甲基化时代来了！！！ |
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| 【JAK信号通路】TG101209(EY0319) |
| TG101209是JAK2选择性抑制剂，IC50为6 nM，对Flt3和RET的IC50为25 nM和17 nM，比对JAK3的抑制性高30倍，对JAK2V617F和MPLW515L/K突变型敏感，还能抑制BRD4，IC50为130 nM
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| 【JAK信号通路】GLPG0634 analogue(EY1118) |
GLPG0634 analogue is a selective JAK1 inhibitor with IC50 of 10 nM, 28 nM, 810 nM, and 116 nM for JAK1, JAK2, JAK3, and TYK2, respectively.
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| 【STAT信号通路】Cucurbitacin I (EY2197) |
| Selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces ap
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